NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase
نویسندگان
چکیده
منابع مشابه
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase.
Poly(ADP-ribose) polymerase (PARP-1), a nuclear enzyme that facilitates DNA repair, may be instrumental in acute neuronal cell death in a variety of insults including, cerebral ischemia, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism, and CNS trauma. Excitotoxicity is thought to underlie these and other toxic models of neuronal death. Different glutamate agonists may trigger ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2000
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.20-21-08005.2000